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USP30 inhibition augments mitophagy to prevent T cell exhaustion

15 Aug 2025

Abstract excerpt

The exhaustion of tumor-infiltrating CD8 + T cells poses a substantial challenge in cancer immunotherapy, with mitochondrial health essential for sustaining T cell functionality. Mitophagy, a critical process for mitochondrial quality control, is severely impaired in exhausted CD8 + T cells, yet the underlying mechanisms remain unclear. We identified ubiquitin-specific protease 30 (USP30), a mitochondrial...

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PMID: 40815646
DOI: 10.1126/sciadv.adv6902

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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