Article

USP18 Inhibition Enhances Type I Interferon Signalling and Immune Activation in the Tumour Microenvironment of Triple-Negative Breast Cancer

2025-09-04

Abstract excerpt

Triple-negative breast cancer (TNBC) is one of the most aggressive and treatment-resistant breast cancers. Although immunotherapy has emerged as a promising treatment option, clinical benefit is limited, with only around half of patients responding, even when combined with standard chemotherapeutic agents. This limited efficacy is often attributed to immunologically “cold” tumour microenvironments (TME), which are...

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Literature Corpus work: 6ceec6e4-80a2-547b-8057-9f9e845dbf64
DOI: 10.1101/2025.09.01.672152

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