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USP14 promotes tryptophan metabolism and immune suppression by stabilizing IDO1 in colorectal cancer

26 Sept 2022

Abstract excerpt

Indoleamine 2,3 dioxygenase 1 (IDO1) is an attractive target for cancer immunotherapy. However, IDO1 inhibitors have shown disappointing therapeutic efficacy in clinical trials, mainly because of the activation of the aryl hydrocarbon receptor (AhR). Here, we show a post-transcriptional regulatory mechanism of IDO1 regulated by a proteasome-associated deubiquitinating enzyme, USP14, in colorectal cancer (CRC)....

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PMID: 36163134
DOI: 10.1038/s41467-022-33285-x

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