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Article

USP13 promotes breast cancer metastasis through FBXL14-induced Twist1 ubiquitination

2 Feb 2023

Abstract excerpt

PURPOSE: Epithelial-to-mesenchymal transition (EMT) is an important cause of high mortality in breast cancer. Twist1 is one of the EMT transcription factors (EMT-TFs) with a noticeably short half-life, which is regulated by proteasome degradation pathways. Recent studies have found that USP13 stabilizes several specific oncogenic proteins. As yet, however, the relationship between Twist1 and USP13 has not been...

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PMID: 36732432
DOI: 10.1007/s13402-023-00779-9

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