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Article

Structure of a Hallucinogen-Activated Gq-Coupled 5-HT2A Serotonin Receptor.

Cell - 17 Sept 2020

Kim Kuglae, Che Tao, Panova Ouliana, DiBerto Jeffrey F, Lyu Jiankun, Krumm Brian E, Wacker Daniel, Robertson Michael J, Seven Alpay B, Nichols David E, Shoichet Brian K, Skiniotis Georgios, Roth Bryan L

Abstract excerpt

Hallucinogens like lysergic acid diethylamide (LSD), psilocybin, and substituted N-benzyl phenylalkylamines are widely used recreationally with psilocybin being considered as a therapeutic for many neuropsychiatric disorders including depression, anxiety, and substance abuse. How psychedelics mediate their actions-both therapeutic and hallucinogenic-are not understood, although activation of the 5-HT2A serotonin...

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Identifiers

PMID: 32946782
DOI: 10.1016/j.cell.2020.08.024
PMCID: PMC7593816

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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