Article
Bitter taste TAS2R14 activation by intracellular tastants and cholesterol.
Nature - 1 Jul 2024
Hu Xiaolong, Ao Weizhen, Gao Mingxin, Wu Lijie, Pei Yuan, Liu Shenhui, Wu Yiran, Zhao Fei, Sun Qianqian, Liu Junlin, Jiang Longquan, Wang Xin, Li Yan, Tan Qiwen, Cheng Jie, Yang Fan, Yang Chi, Sun Jinpeng, Hua Tian, Liu Zhi-Jie
Abstract excerpt
Bitter taste receptors, particularly TAS2R14, play central roles in discerning a wide array of bitter substances, ranging from dietary components to pharmaceutical agents1,2. TAS2R14 is also widely expressed in extragustatory tissues, suggesting its extra roles in diverse physiological processes and potential therapeutic applications3. Here we present cryogenic electron microscopy structures of TAS2R14 in complex...
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