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Article

Essential role of the C148-C227 disulphide bridge in the human 5-HT2A homodimeric receptor.

Biochemical pharmacology - 1 Jul 2020

Cimadevila M, Gómez-García L, Martínez A L, Iglesias A, López-Giménez J, Castro M, Cadavid M I, Loza M I, Brea J

Abstract excerpt

The 5-HT2A receptor is a homodimeric G protein-coupled receptor implied in multiple diseases, including schizophrenia. Recently, its co-crystallisation with the antipsychotic drugs zotepine and risperidone has revealed the importance of its extracellular domains in its pharmacology. Previous studies have shown that the non-specific disruption of extracellular disulphide bridges in the 5-HT2A receptor decreases...

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PMID: 32311347
DOI: 10.1016/j.bcp.2020.113985

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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