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Cryo-EM structure of the human histamine H1 receptor/Gq complex

7 Apr 2021

Abstract excerpt

Abstract Histamine receptors play important roles in various pathophysiological conditions and are effective targets for anti-allergy treatment, however the mechanism of receptor activation remain elusive. Here, we present the cryo-electron microscopy (cryo-EM) structure of the human H 1 R in complex with a G q protein in an active conformation via a NanoBiT tethering strategy. The structure reveals that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33828102
DOI: 10.1038/s41467-021-22427-2

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