Article

Structural Genomics of the Human Dopamine Receptor System

2022-10-10

Abstract excerpt

The dopamine system, including five dopamine receptors (D1R to D5R), plays essential roles in the central nervous system (CNS) and ligands that activate dopamine receptors have been used to treat many neuropsychiatric disorders, including Parkinson’s Disease (PD) and schizophrenia. Here, we report five cryo-EM structures of all subtypes of human dopamine receptors in complex with G-protein and bound to the pan ago...

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Literature Corpus work: af375685-b0d0-5592-aa4d-275d48ecc771
DOI: 10.1101/2022.10.09.511478

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