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Article

Serine residues 13 and 16 are key modulators of mutant huntingtin induced toxicity in Drosophila.

Experimental neurology - 1 Apr 2021

Chatterjee Megha, Steffan Joan S, Lukacsovich Tamas, Marsh J Lawrence, Agrawal Namita

Abstract excerpt

Poly-glutamine expansion near the N-terminus of the huntingtin protein (HTT) is the prime determinant of Huntington's disease (HD) pathology; however, post-translational modifications and protein context are also reported to influence poly-glutamine induced HD toxicity. The impact of phosphorylating serine 13/16 of mutant HTT (mHTT) on HD has been documented in cell culture and murine models. However, endogenous...

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Identifiers

PMID: 32941796
DOI: 10.1016/j.expneurol.2020.113463

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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