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Article

Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice.

Neuron - 24 Dec 2009

Gu Xiaofeng, Greiner Erin R, Mishra Rakesh, Kodali Ravindra, Osmand Alex, Finkbeiner Steven, Steffan Joan S, Thompson Leslie Michels, Wetzel Ronald, Yang X William

Abstract excerpt

The N-terminal 17 amino acids of huntingtin (NT17) can be phosphorylated on serines 13 and 16; however, the significance of these modifications in Huntington's disease pathogenesis remains unknown. In this study, we developed BAC transgenic mice expressing full-length mutant huntingtin (fl-mhtt) with serines 13 and 16 mutated to either aspartate (phosphomimetic or SD) or alanine (phosphoresistant or SA). Both...

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Identifiers

PMID: 20064390
DOI: 10.1016/j.neuron.2009.11.020
PMCID: PMC2807408

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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