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Article

Preferential accumulation of N-terminal mutant huntingtin in the nuclei of striatal neurons is regulated by phosphorylation.

Human molecular genetics - 1 Apr 2011

Havel Lauren S, Wang Chuan-En, Wade Brandy, Huang Brenda, Li Shihua, Li Xiao-Jiang

Abstract excerpt

An expanded polyglutamine tract (>37 glutamines) in the N-terminal region of huntingtin (htt) causes htt to accumulate in the nucleus, leading to transcriptional dysregulation in Huntington disease (HD). In HD knock-in mice that express full-length mutant htt at the endogenous level, mutant htt preferentially accumulates in the nuclei of striatal neurons, which are affected most profoundly in HD. The mechanism...

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Identifiers

PMID: 21245084
DOI: 10.1093/hmg/ddr023
PMCID: PMC3049362

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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