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Article

N-terminal Huntingtin (Htt) phosphorylation is a molecular switch regulating Htt aggregation, helical conformation, internalization, and nuclear targeting.

The Journal of biological chemistry - 30 Nov 2018

DeGuire Sean M, Ruggeri Francesco S, Fares Mohamed-Bilal, Chiki Anass, Cendrowska Urszula, Dietler Giovanni, Lashuel Hilal A

Abstract excerpt

Huntington's disease is a fatal neurodegenerative disorder resulting from a CAG repeat expansion in the first exon of the gene encoding the Huntingtin protein (Htt). Phosphorylation of this protein region (Httex1) has been shown to play important roles in regulating the structure, toxicity, and cellular properties of N-terminal fragments and full-length Htt. However, increasing evidence suggests that...

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Identifiers

PMID: 30185623
DOI: 10.1074/jbc.RA118.004621
PMCID: PMC6290154

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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