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Phosphomimetic Mutations Impact Huntingtin Aggregation in the Presence of a Variety of Lipid Systems.

Biochemistry - 15 Dec 2020

Groover Sharon E, Beasley Maryssa, Ramamurthy Visvanathan, Legleiter Justin

Abstract excerpt

Huntington's disease (HD) is a neurodegenerative disorder caused by the abnormal expansion of a polyglutamine (polyQ) tract in the first exon of the htt protein (htt). PolyQ expansion triggers the aggregation of htt into a variety of structures, including oligomers and fibrils. This aggregation is impacted by the first 17 N-terminal amino acids (Nt17) of htt that directly precedes the polyQ domain. Beyond...

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Biophysical Phenomena
Huntingtin Protein
Huntington Disease
In Vitro Techniques
Microscopy, Atomic Force

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Mimicry

Protein Aggregates

Protein Aggregation, Pathological

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PMID: 33256402
DOI: 10.1021/acs.biochem.0c00788

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Phosphomimetic Mutations Impact Huntingtin Aggregation in the Presence of a Variety of Lipid Systems.PMID 33256402Read ↗

N-terminal Huntingtin (Htt) phosphorylation is a molecular switch regulating Htt aggregation, helical conformation, internalization, and nuclear targeting.Semantic proximity Read ↗

Regulation of Mutant Huntingtin Mitochondrial Toxicity by Phosphomimetic Mutations within Its N-Terminal Region.Semantic proximity Read ↗

Serine phosphorylation suppresses huntingtin amyloid accumulation by altering protein aggregation properties.Semantic proximity Read ↗

Membranes as targets and modifiers of mutant huntingtin aggregation.Semantic proximity Read ↗

Mutant Exon1 Huntingtin Aggregation is Regulated by T3 Phosphorylation-Induced Structural Changes and Crosstalk between T3 Phosphorylation and Acetylation at K6.Semantic proximity Read ↗

Lipid Composition Drives Mutant Huntingtin Dimerization and Membrane Association: Insights from Computational Simulations.Semantic proximity Read ↗

Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice.Semantic proximity Read ↗

Protein phosphatase 1 regulates huntingtin exon 1 aggregation and toxicitySemantic proximity Read ↗

Protein phosphatase 1 regulates huntingtin exon 1 aggregation and toxicity.Semantic proximity Read ↗

Serine residues 13 and 16 are key modulators of mutant huntingtin induced toxicity in Drosophila.Semantic proximity Read ↗

The Nt17 Domain and its Helical Conformation Regulate the Aggregation, Cellular Properties and Neurotoxicity of Mutant Huntingtin Exon 1.Semantic proximity Read ↗

Rescue of aberrant huntingtin palmitoylation ameliorates mutant huntingtin-induced toxicitySemantic proximity Read ↗

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