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Article

Post-translational modifications clustering within proteolytic domains decrease mutant huntingtin toxicity.

The Journal of biological chemistry - 24 Nov 2017

Arbez Nicolas, Ratovitski Tamara, Roby Elaine, Chighladze Ekaterine, Stewart Jacqueline C, Ren Mark, Wang Xiaofang, Lavery Daniel J, Ross Christopher A

Abstract excerpt

Huntington's disease (HD) is caused in large part by a polyglutamine expansion within the huntingtin (Htt) protein. Post-translational modifications (PTMs) control and regulate many protein functions and cellular pathways, and PTMs of mutant Htt are likely important modulators of HD pathogenesis. Alterations of selected numbers of PTMs of Htt fragments have been shown to modulate Htt cellular localization and...

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Identifiers

PMID: 28972180
DOI: 10.1074/jbc.M117.782300
PMCID: PMC5702665

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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