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Protein phosphatase 1 regulates huntingtin exon 1 aggregation and toxicity.

Human molecular genetics - 1 Oct 2017

Branco-Santos Joana, Herrera Federico, Poças Gonçalo M, Pires-Afonso Yolanda, Giorgini Flaviano, Domingos Pedro M, Outeiro Tiago F

Abstract excerpt

Huntington's disease is neurodegenerative disorder caused by a polyglutamine expansion in the N-terminal region of the huntingtin protein (N17). Here, we analysed the relative contribution of each phosphorylatable residue in the N17 region (T3, S13 and S16) towards huntingtin exon 1 (HTTex1) oligomerization, aggregation and toxicity in human cells and Drosophila neurons. We used bimolecular fluorescence...

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PMID: 28934390
DOI: 10.1093/hmg/ddx260

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