Article

Protein phosphatase 1 regulates huntingtin exon 1 aggregation and toxicity

2017-05-10

Abstract excerpt

Huntington’s disease (HD) is neurodegenerative disorder caused by a polyglutamine expansion in the N-terminal region of the huntingtin protein (N17). Here, we analysed the relative contribution of each phosphorylatable residue in the N17 region (T3, S13 and S16) towards huntingtin exon 1 (HTTex1) oligomerization, aggregation and toxicity in human cells and Drosophila neurons. We used bimolecular fluorescence comp...

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Literature Corpus work: ca2454ce-b5e2-5781-b3fb-01df48ecf890
DOI: 10.1101/135954

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