Association of 3p27.1 Variants with Whole Body Lean Mass Identified by a Genome-wide Association Study.

doi:10.1038/s41598-020-61272-z

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Association of 3p27.1 Variants with Whole Body Lean Mass Identified by a Genome-wide Association Study.

Scientific reports - 9 Mar 2020

Ran Shu, Zhang Yu-Xue, Liu Lu, Jiang Zi-Xuan, He Xiao, Liu Yu, Shen Hui, Tian Qing, Pei Yu-Fang, Deng Hong-Wen, Zhang Lei

Abstract excerpt

Whole body lean mass (WBLM) is a heritable trait predicting sarcopenia. To identify genomic locus underlying WBLM, we performed a genome-wide association study of fat-adjusted WBLM in the Framingham Heart Study (FHS, N = 6,004), and replicated in the Kansas City Osteoporosis Study (KCOS, N = 2,207). We identified a novel locus 3p27.1 that was associated with WBLM (lead SNP rs3732593 P = 7.19 × 10-8) in the...

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PMID: 32152362
DOI: 10.1038/s41598-020-61272-z
PMCID: PMC7062907

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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