Article
Mutational specificity of thymine deprivation-induced mutation in the lacI gene of Escherichia coli.
Mutation research - 1 Jan 2000
Glickman B W, Allen F L, Horsfall M J
Abstract excerpt
LacI- mutants obtained following 2 and 6 h of thymine deprivation were cloned and sequenced. The mutational spectra recovered were dissimilar. After 2 h of starvation the majority of mutations were base substitutions, largely G:C----C:G transversions. Frameshift mutations but not deletions were observed. In contrast, following 6 h of starvation, with the exception of the G:C----C:G transversion, all possible base...
Topics
- Base Sequence
- Chromosome Deletion
- DNA Mutational Analysis
- DNA Repair
- DNA Replication
- Escherichia coli
- Lac Operon
- Mutation
- Thymine
- Time Factors