Mutation frequency decline revisited.

doi:10.1002/bies.950160613

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Article

Mutation frequency decline revisited.

BioEssays : news and reviews in molecular, cellular and developmental biology - 1 Jun 1994

Witkin E M

Abstract excerpt

'Mutation frequency decline' (MFD) was discovered about forty years ago, and described as the disappearance of a particular class of ultraviolet light-induced mutations in Escherichia coli that occurred whenever protein synthesis was briefly inhibited immediately after irradiation. Later, MFD was interpreted as an excision repair anomaly uniquely affecting nonsense suppressor mutations induced in certain tRNA...

Topics

Bacterial Proteins
Base Sequence
DNA Repair
Escherichia coli
Genes, Bacterial
Genes, Suppressor
History, 20th Century
Models, Genetic
Molecular Biology
Molecular Sequence Data
Mutagenesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Protein Synthesis Inhibitors

RNA, Bacterial

RNA, Transfer, Gln

Transcription Factors

Transcription, Genetic

Ultraviolet Rays

Source

Open in PubMed

Identifiers

PMID: 7521640
DOI: 10.1002/bies.950160613

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7521640-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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