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Article

Spontaneous mutation in the Escherichia coli lacI gene.

Genetics - 1 Oct 1991

Schaaper R M, Dunn R L

Abstract excerpt

To gain more detailed insight into the nature and mechanisms of spontaneous mutations, we undertook a DNA sequence analysis of a large collection of spontaneous mutations in the N-terminal region of the Escherichia coli lacI gene. This region of circa 210 base pairs is the target for dominant lacI mutations (i-d) and is suitable for studies of mutational specificity since it contains a relatively high density of...

Topics

Bacterial Proteins
Base Composition
Base Sequence
Chromosome Deletion
Chromosomes, Bacterial
DNA Transposable Elements
DNA, Bacterial
Escherichia coli
Escherichia coli Proteins
Frameshift Mutation
Lac Operon

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lac Repressors

Molecular Sequence Data

Mutation

Repetitive Sequences, Nucleic Acid

Repressor Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 1660424
DOI: 10.1093/genetics/129.2.317
PMCID: PMC1204625

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1660424-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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