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Article

Mutational specificity of thymine nucleotide depletion in yeast.

Mutation research - 1 Sept 1993

Kohalmi S E, Kunz B A

Abstract excerpt

Relative to normal growth conditions for a wild-type strain of the yeast Saccharomyces cerevisiae, withholding thymidylate (dTMP) severely diminished the dTTP pool but elevated the dATP, dGTP and dCTP levels (120-, 8.5- and 3.6-fold, respectively) in an isogenic dTMP auxotroph. This treatment also increased the frequency of mutations in a tRNA gene (SUP4-o) by 15-fold. Single base-pair events accounted for 97% of...

Topics

Base Sequence
Molecular Sequence Data
Mutation
RNA, Transfer
Saccharomyces cerevisiae
Thymidine Monophosphate
Thymine Nucleotides

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 7689166
DOI: 10.1016/0027-5107(93)90132-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7689166-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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