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Article

The solution structure of the complement deregulator FHR5 reveals a compact dimer and provides new insights into CFHR5 nephropathy.

The Journal of biological chemistry - 27 Nov 2020

Kadkhodayi-Kholghi Nilufar, Bhatt Jayesh S, Gor Jayesh, McDermott Lindsay C, Gale Daniel P, Perkins Stephen J

Abstract excerpt

The human complement Factor H-related 5 protein (FHR5) antagonizes the main circulating complement regulator Factor H, resulting in the deregulation of complement activation. FHR5 normally contains nine short complement regulator (SCR) domains, but a FHR5 mutant has been identified with a duplicated N-terminal SCR-1/2 domain pair that causes CFHR5 nephropathy. To understand how this duplication causes disease, we...

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Identifiers

PMID: 32928961
DOI: 10.1074/jbc.RA120.015132
PMCID: PMC7705313

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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