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Dimerization of complement factor H-related proteins modulates complement activation in vivo

4 Mar 2013

Abstract excerpt

The complement system is a key component regulation influences susceptibility to age-related macular degeneration, meningitis, and kidney disease. Variation includes genomic rearrangements within the complement factor H-related (CFHR) locus. Elucidating the mechanism underlying these associations has been hindered by the lack of understanding of the biological role of CFHR proteins. Here we present unique...

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PMID: 23487775
DOI: 10.1073/pnas.1219260110

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