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Article

Molecular bases for the association of FHR-1 with atypical hemolytic uremic syndrome and other diseases.

Blood - 24 Jun 2021

Martin Merinero Héctor, Subías Marta, Pereda Amaia, Gómez-Rubio Elena, Juana Lopez Lucia, Fernandez Constantino, Goicoechea de Jorge Elena, Martin-Santamaria Sonsoles, Cañada Francisco Javier, Rodríguez de Córdoba Santiago

Abstract excerpt

Factor H (FH)-related proteins are a group of partly characterized complement proteins thought to promote complement activation by competing with FH in binding to surface-bound C3b. Among them, FH-related protein 1 (FHR-1) is remarkable because of its association with atypical hemolytic uremic syndrome (aHUS) and other important diseases. Using a combination of biochemical, immunological, nuclear magnetic...

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Identifiers

PMID: 33651882
DOI: 10.1182/blood.2020010069
PMCID: PMC8288665

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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