Article
Structure, function and control of complement C5 and its proteolytic fragments.
Current molecular medicine - 1 Sept 2012
Laursen N S, Magnani F, Gottfredsen R H, Petersen S V, Andersen G R
Abstract excerpt
As part of the innate immune system, the complement system recognises a wide range of non-self structures present on pathogens or altered self cells. Its activation elicits proteolytic cascades which eventually results in the cleavage of the C5 protein into two fragments, C5a and C5b. The small anaphylatoxin C5a induces a variety of biological responses upon binding to the 7TM receptors C5aR and the C5L2, while...
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