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High-Resolution Melt Curve Analysis in Cancer Mutation Screen.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2016

Mehrotra Meenakshi, Patel Keyur P

Abstract excerpt

High-resolution melt (HRM) curve analysis is a PCR-based assay that identifies sequence alterations based on subtle variations in the melting curves of mutated versus wild-type DNA sequences. HRM analysis is a high-throughput, sensitive, and efficient alternative to Sanger sequencing and is used to assess for mutations in clinically important genes involved in cancer diagnosis. The technique involves PCR...

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PMID: 26843047
DOI: 10.1007/978-1-4939-3360-0_7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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