Article
Impact of admixture and ancestry on eQTL analysis and GWAS colocalization in GTEx.
Genome biology - 11 Sept 2020
Gay Nicole R, Gloudemans Michael, Antonio Margaret L, Abell Nathan S, Balliu Brunilda, Park YoSon, Martin Alicia R, Musharoff Shaila, Rao Abhiram S, Aguet François, Barbeira Alvaro N, Bonazzola Rodrigo, Hormozdiari Farhad, Ardlie Kristin G, Brown Christopher D, Im Hae Kyung, Lappalainen Tuuli, Wen Xiaoquan, Montgomery Stephen B
Abstract excerpt
BACKGROUND: Population structure among study subjects may confound genetic association studies, and lack of proper correction can lead to spurious findings. The Genotype-Tissue Expression (GTEx) project largely contains individuals of European ancestry, but the v8 release also includes up to 15% of individuals of non-European ancestry. Assessing ancestry-based adjustments in GTEx improves portability of this...
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