Article
Full-length sequence analysis of hepatitis C virus genotype 3b strains and development of an in vivo infectious 3b cDNA clone.
Journal of virology - 21 Dec 2023
Bajpai Priyanka Shukla, Collignon Laura, Sølund Christina, Madsen Lone Wulff, Christensen Peer Brehm, Øvrehus Anne, Weis Nina, Holmbeck Kenn, Fahnøe Ulrik, Bukh Jens
Abstract excerpt
IMPORTANCE: HCV genotype 3b is a difficult-to-treat subtype, associated with accelerated progression of liver disease and resistance to antivirals. Moreover, its prevalence has significantly increased among persons who inject drugs posing a serious risk of transmission in the general population. Thus, more genetic information and antiviral testing systems are required to develop novel therapeutic options for this...
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