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Article

Robust HCV Genotype 3a Infectious Cell Culture System Permits Identification of Escape Variants With Resistance to Sofosbuvir.

Gastroenterology - 1 Nov 2016

Ramirez Santseharay, Mikkelsen Lotte S, Gottwein Judith M, Bukh Jens

Abstract excerpt

BACKGROUND & AIMS: Direct-acting antivirals (DAAs) effectively eradicate chronic hepatitis C virus (HCV) infection, although HCV genotype 3a is less responsive to these drugs. We aimed to develop genotype 3a infectious cultures and study the effects of inhibitors of NS5A and NS5B and resistance to sofosbuvir-the only nucleotide analog approved for treatment of chronic HCV infection. METHODS: The developed HCV...

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Identifiers

PMID: 27453546
DOI: 10.1053/j.gastro.2016.07.013

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