Article
Statistically efficient association analysis of quantitative traits with haplotypes and untyped SNPs in family studies.
BMC genetics - 7 Sept 2020
Diao Guoqing, Lin Dan-Yu
Abstract excerpt
BACKGROUND: Associations between haplotypes and quantitative traits provide valuable information about the genetic basis of complex human diseases. Haplotypes also provide an effective way to deal with untyped SNPs. Two major challenges arise in haplotype-based association analysis of family data. First, haplotypes may not be inferred with certainty from genotype data. Second, the trait values within a family...
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