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Article

A general framework for robust and efficient association analysis in family-based designs: quantitative and dichotomous phenotypes.

Statistics in medicine - 10 Nov 2013

Won Sungho, Lange Christoph

Abstract excerpt

Although transmission disequilibrium tests (TDT) and the FBAT statistic are robust against population substructure, they have reduced statistical power, as compared with fully efficient tests that are not guarded against confounding because of population substructure. This has often limited the application of transmission disequilibrium tests/FBATs to candidate gene analysis, because, in a genome-wide association...

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PMID: 23740776
DOI: 10.1002/sim.5865

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