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Article

The Interaction of CtIP and Nbs1 Connects CDK and ATM to Regulate HR–Mediated Double-Strand Break Repair

28 Feb 2013

Abstract excerpt

CtIP plays an important role in homologous recombination (HR)-mediated DNA double-stranded break (DSB) repair and interacts with Nbs1 and BRCA1, which are linked to Nijmegen breakage syndrome (NBS) and familial breast cancer, respectively. We identified new CDK phosphorylation sites on CtIP and found that phosphorylation of these newly identified CDK sites induces association of CtIP with the N-terminus FHA and...

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Identifiers

PMID: 23468639
DOI: 10.1371/journal.pgen.1003277

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Interaction of CtIP and Nbs1 Connects CDK and ATM to Regulate HR–Mediated Double-Strand Break RepairPMID 23468639Read ↗

Controlling DNA-end resection: a new task for CDKsSemantic proximity Read ↗

ATM antagonizes NHEJ proteins assembly and DNA-ends synapsis at single-ended DNA double strand breaksSemantic proximity Read ↗

CSB interacts with BRCA1 in late S/G2 to promote MRN- and CtIP-mediated DNA end resectionSemantic proximity Read ↗

Plk1 and CK2 Act in Concert to Regulate Rad51 during DNA Double Strand Break RepairSemantic proximity Read ↗

Coordinated nuclease activities counteract Ku at single-ended DNA double-strand breaksSemantic proximity Read ↗

Nbs1 flexibly tethers Ctp1 and Mre11-Rad50 to coordinate DNA double-strand break processing and repair.Semantic proximity Read ↗

CtIP-mediated resection is essential for viability and can operate independently of BRCA1.Semantic proximity Read ↗

ATM priming and end resection–coupled phosphorylation of MRE11 is important for fork protection and replication restartSemantic proximity Read ↗

DNA damage-induced phosphorylation of CtIP at a conserved ATM/ATR site T855 promotes lymphomagenesis in mice.Semantic proximity Read ↗

CtIP protein dimerization is critical for its recruitment to chromosomal DNA double-stranded breaks.Semantic proximity Read ↗

On Broken Ne(c)ks and Broken DNA: The Role of Human NEKs in the DNA Damage ResponseSemantic proximity Read ↗

CDK1 phosphorylates WRN at collapsed replication forksSemantic proximity Read ↗

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