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Coordinated nuclease activities counteract Ku at single-ended DNA double-strand breaks

19 Sept 2016

Abstract excerpt

Repair of single-ended DNA double-strand breaks (seDSBs) by homologous recombination (HR) requires the generation of a 3' single-strand DNA overhang by exonuclease activities in a process called DNA resection. However, it is anticipated that the highly abundant DNA end-binding protein Ku sequesters seDSBs and shields them from exonuclease activities. Despite pioneering works in yeast, it is unclear how mammalian...

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PMID: 27641979
DOI: 10.1038/ncomms12889

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