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Article

Effects of tacrolimus intrapatient variability and CYP3A5 polymorphism on the outcomes of pediatric kidney transplantation.

Pediatric transplantation - 1 Sept 2022

Choi Jin Sun, Ko Hyunmin, Kim Hyo Kee, Chung Chris, Han Ahram, Min Seung-Kee, Ha Jongwon, Kang Hee Gyung, Ha Il Soo, Min Sangil

Abstract excerpt

BACKGROUND: The intrapatient variability (IPV) of tacrolimus (Tac) is associated with the long-term outcome of kidney transplantation. The CYP3A single-nucleotide polymorphism (SNP) may affect the IPV of Tac. We investigated the impact of IPV and genetic polymorphism in pediatric patients who received kidney transplantation. METHODS: A total of 202 pediatric renal transplant recipients from 2000 to 2016 were...

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PMID: 35466485
DOI: 10.1111/petr.14297

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