Article
CYP3A5 genotype is not related to the intrapatient variability of tacrolimus clearance.
Therapeutic drug monitoring - 1 Jun 2011
Pashaee Nilufar, Bouamar Rachida, Hesselink Dennis A, Roodnat Joke I, van Schaik Ron H N, Weimar Willem, van Gelder Teun
Abstract excerpt
BACKGROUND: The risk of long-term chronic allograft nephropathy and graft loss after kidney transplantation is increased in patients with a high intrapatient variability of tacrolimus (Tac) clearance. METHODS: To test whether this intrapatient variability is associated with an individual's CYP3A5 genotype, we measured the intrapatient variability in Tac clearance in a cohort of 208 kidney transplant recipients...
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