A noncoding regulatory variant in IKZF1 increases acute lymphoblastic leukemia risk in Hispanic/Latino children.

doi:10.1016/j.xgen.2024.100526

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

A noncoding regulatory variant in IKZF1 increases acute lymphoblastic leukemia risk in Hispanic/Latino children.

Cell genomics - 10 Apr 2024

de Smith Adam J, Wahlster Lara, Jeon Soyoung, Kachuri Linda, Black Susan, Langie Jalen, Cato Liam D, Nakatsuka Nathan, Chan Tsz-Fung, Xia Guangze, Mazumder Soumyaa, Yang Wenjian, Gazal Steven, Eng Celeste, Hu Donglei, Burchard Esteban González, Ziv Elad, Metayer Catherine, Mancuso Nicholas, Yang Jun J, Ma Xiaomei, Wiemels Joseph L, Yu Fulong, Chiang Charleston W K, Sankaran Vijay G

Abstract excerpt

Hispanic/Latino children have the highest risk of acute lymphoblastic leukemia (ALL) in the US compared to other racial/ethnic groups, yet the basis of this remains incompletely understood. Through genetic fine-mapping analyses, we identified a new independent childhood ALL risk signal near IKZF1 in self-reported Hispanic/Latino individuals, but not in non-Hispanic White individuals, with an effect size of ∼1.44...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Child

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to IKZF1 gene

Share to Genetic Predisposition to Disease

Share to Hispanic or Latino

Share to Ikaros Transcription Factor

Share to Polymorphism, Single Nucleotide

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Share to Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 38537633
DOI: 10.1016/j.xgen.2024.100526
PMCID: PMC11019360

Genes

IKZF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A noncoding regulatory variant in IKZF1 increases acute lymphoblastic leukemia risk in Hispanic/Latino children.PMID 38537633Read ↗

GWAS in childhood acute lymphoblastic leukemia reveals novel genetic associations at chromosomes 17q12 and 8q24.21.Semantic proximity Read ↗

Genetic markers in a multi-ethnic sample for childhood acute lymphoblastic leukemia risk.Semantic proximity Read ↗

Novel susceptibility variants at 10p12.31-12.2 for childhood acute lymphoblastic leukemia in ethnically diverse populations.Semantic proximity Read ↗

Family-based exome-wide association study of childhood acute lymphoblastic leukemia among Hispanics confirms role of ARID5B in susceptibility.Semantic proximity Read ↗

Genome-wide association study of childhood B-cell acute lymphoblastic leukemia reveals novel African ancestry-specific susceptibility loci.Semantic proximity Read ↗

Genetic variants in ARID5B and CEBPE are childhood ALL susceptibility loci in Hispanics.Semantic proximity Read ↗

Genetic susceptibility in childhood acute lymphoblastic leukemia.Semantic proximity Read ↗

Investigating DNA methylation as a mediator of genetic risk in childhood acute lymphoblastic leukemia.Semantic proximity Read ↗

Genome-Wide Association Study of Susceptibility Loci for TCF3-PBX1 Acute Lymphoblastic Leukemia in Children.Semantic proximity Read ↗

Novel susceptibility variants at the ERG locus for childhood acute lymphoblastic leukemia in HispanicsSemantic proximity Read ↗

Family-based exome-wide assessment of maternal genetic effects on susceptibility to childhood B-cell acute lymphoblastic leukemia in hispanics.Semantic proximity Read ↗

Genetic defects in hematopoietic transcription factors and predisposition to acute lymphoblastic leukemiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.