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Article

POLQ suppresses interhomolog recombination and loss of heterozygosity at targeted DNA breaks.

Proceedings of the National Academy of Sciences of the United States of America - 15 Sept 2020

Davis Luther, Khoo Kevin J, Zhang Yinbo, Maizels Nancy

Abstract excerpt

Interhomolog recombination (IHR) occurs spontaneously in somatic human cells at frequencies that are low but sufficient to ameliorate some genetic diseases caused by heterozygous mutations or autosomal dominant mutations. Here we demonstrate that DNA nicks or double-strand breaks (DSBs) targeted by CRISPR-Cas9 to both homologs can stimulate IHR and associated copy-neutral loss of heterozygosity (cnLOH) in human...

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Share to CRISPR-Cas Systems
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32873648
DOI: 10.1073/pnas.2008073117
PMCID: PMC7502765

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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