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Article

An Acidic Environment Induces APOL1-Associated Mitochondrial Fragmentation.

American journal of nephrology - 1 Jan 2020

Li DengFeng, Snipes James A, Murea Mariana, Molina Anthony J A, Divers Jasmin, Freedman Barry I, Ma Lijun, Petrovic Snezana

Abstract excerpt

BACKGROUND: Apolipoprotein L1 gene (APOL1) G1 and G2 kidney-risk variants (KRVs) cause CKD in African Americans, inducing mitochondrial dysfunction. Modifying factors are required, because a minority of individuals with APOL1 high-risk genotypes develop nephropathy. Given that APOL1 function is pH-sensitive and the pH of the kidney interstitium is <7, we hypothesized the acidic kidney interstitium may facilitate...

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Identifiers

PMID: 32866949
DOI: 10.1159/000509989
PMCID: PMC7511450

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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