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Article

APOL1 Risk Variants Impair Multiple Mitochondrial Pathways in a Metabolomics Analysis.

Kidney360 - 31 Dec 2020

Ma Lijun, Palmer Nicholette D, Choi Young A, Murea Mariana, Snipes James A, Parks John S, Langefeld Carl D, Freedman Barry I

Abstract excerpt

Background: Kidney risk variants (KRVs) in the APOL1 gene are associated with mitochondrial dysfunction. However, the molecular spectrum of metabolites affected by the G1 and G2 KRVs, and the downstream mitochondrial pathways they affect, remain unknown. Methods: We performed a metabolomics analysis using HEK293 Tet-on cells conditionally expressing APOL1 G0, G1, and G2 KRVs to determine the patterns of...

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Share to Apolipoprotein L1
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 35372896
DOI: 10.34067/KID.0003592020
PMCID: PMC8815529

Genes

APOL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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