Article

Genomewide Screen Identifies Peroxisomal Role in APOL1 Podocytopathy

2025-02-18

Abstract excerpt

<h4>ABSTRACT</h4> The G1 and G2 variants of the APOL1 gene increase the risk of chronic kidney disease (CKD) in individuals of African descent. In the presence of secondary stressors such as inflammation and hypoxia, these gain-of-function variants can induce podocyte dysfunction and cell death through mechanisms that are not fully understood. To identify genes that influence the cytotoxic effects of APOL1 variant...

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Literature Corpus work: 9100ae0f-53aa-5c01-99ea-e5306eb8b30a
DOI: 10.1101/2025.02.15.25322241

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