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Recruitment of APOL1 kidney disease risk variants to lipid droplets attenuates cell toxicity

7 Feb 2019

Abstract excerpt

Two coding variants in the apolipoprotein L1 (APOL1) gene (termed G1 and G2) are strongly associated with increased risk of nondiabetic kidney disease in people of recent African ancestry. The mechanisms by which the risk variants cause kidney damage, although not well-understood, are believed to involve injury to glomerular podocytes. The intracellular localization and function of APOL1 in podocytes remain...

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PMID: 30733285
DOI: 10.1073/pnas.1820414116

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