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Article

APOL1 Renal-Risk Variants Induce Mitochondrial Dysfunction

7 Nov 2016

Abstract excerpt

APOL1 G1 and G2 variants facilitate kidney disease in blacks. To elucidate the pathways whereby these variants contribute to disease pathogenesis, we established HEK293 cell lines stably expressing doxycycline-inducible (Tet-on) reference APOL1 G0 or the G1 and G2 renal-risk variants, and used Illumina human HT-12 v4 arrays and Affymetrix HTA 2.0 arrays to generate global gene expression data with doxycycline...

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PMID: 27821631
DOI: 10.1681/asn.2016050567

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