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Article

APOL1 Kidney-Risk Variants Induce Mitochondrial Fission.

1 Jun 2020

Abstract excerpt

INTRODUCTION: -nephropathy. METHODS: A global gene expression analysis was performed in human primary renal tubule cell lines derived from 50 African American individuals. Follow-up gene knock out, cell-based rescue, and microscopy experiments were performed. RESULTS: G0, G1, and G2 were created; G0 cells appeared to promote mitochondrial fusion, whereas G1 and G2 induced mitochondrial fission. The mitochondrial...

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Share to Chronic Kidney Disease and Diabetes
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PMID: 32518871
DOI: 10.1016/j.ekir.2020.03.020

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