Article
Targeting RNA polymerase I transcription and the nucleolus for cancer therapy
17 Jul 2013
Abstract excerpt
The nucleoli are the site of the production of ribosomes, the protein synthetic apparatus of the cell. The presence of enlarged nucleoli, reflecting increased ribosomal gene transcription, has long been used by pathologists as an indicator of aggressive tumors. However, over the last 10 years a growing body of evidence has revealed that the nucleolus contains a dynamic cohort of over 4500 proteins, the majority...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.