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Recent advances in AML with mutated NPM1.

International journal of hematology - 1 Nov 2024

Ishikawa Yuichi, Ushijima Yoko, Kiyoi Hitoshi

Abstract excerpt

Nucleophosmin 1 (NPM1) mutation is one of the most prevalent genetic mutations in adult acute myeloid leukemia (AML) and is particularly predominant in AML with a normal karyotype. NPM1 is a chaperone protein that plays various roles in several cellular processes. Wild-type NPM1 is normally localized to the nucleus, whereas mutant NPM1 proteins exhibit altered cytoplasmic localization. Clinically, AML with...

Topics

Nucleophosmin
Humans
Leukemia, Myeloid, Acute
Nuclear Proteins
Mutation
Molecular Targeted Therapy
Prognosis

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 39174699
DOI: 10.1007/s12185-024-03835-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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