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Article

Recent advances in AML with mutated NPM1.

International journal of hematology - 1 Nov 2024

Ishikawa Yuichi, Ushijima Yoko, Kiyoi Hitoshi

Abstract excerpt

Nucleophosmin 1 (NPM1) mutation is one of the most prevalent genetic mutations in adult acute myeloid leukemia (AML) and is particularly predominant in AML with a normal karyotype. NPM1 is a chaperone protein that plays various roles in several cellular processes. Wild-type NPM1 is normally localized to the nucleus, whereas mutant NPM1 proteins exhibit altered cytoplasmic localization. Clinically, AML with...

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Identifiers

PMID: 39174699
DOI: 10.1007/s12185-024-03835-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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