Article
Structural impact of K63 ubiquitin on yeast translocating ribosomes under oxidative stress.
Proceedings of the National Academy of Sciences of the United States of America - 8 Sept 2020
Zhou Ye, Kastritis Panagiotis L, Dougherty Shannon E, Bouvette Jonathan, Hsu Allen L, Burbaum Laura, Mosalaganti Shyamal, Pfeffer Stefan, Hagen Wim J H, Förster Friedrich, Borgnia Mario J, Vogel Christine, Beck Martin, Bartesaghi Alberto, Silva Gustavo M
Abstract excerpt
Subpopulations of ribosomes are responsible for fine tuning the control of protein synthesis in dynamic environments. K63 ubiquitination of ribosomes has emerged as a new posttranslational modification that regulates protein synthesis during cellular response to oxidative stress. K63 ubiquitin, a type of ubiquitin chain that functions independently of the proteasome, modifies several sites at the surface of the...
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