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A ubiquitin language communicates ribosomal distress

22 Mar 2023

Abstract excerpt

Cells entrust ribosomes with the critical task of identifying problematic mRNAs and facilitating their degradation. Ribosomes must communicate when they encounter and stall on an aberrant mRNA, lest they expose the cell to toxic and disease-causing proteins, or they jeopardize ribosome homeostasis and cellular translation. In recent years, ribosomal ubiquitination has emerged as a central signaling step in this...

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PMID: 36963992
DOI: 10.1016/j.semcdb.2023.03.009

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