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Article

Ubiquitination of stalled ribosome triggers ribosome-associated quality control.

Nature communications - 31 Jul 2017

Matsuo Yoshitaka, Ikeuchi Ken, Saeki Yasushi, Iwasaki Shintaro, Schmidt Christian, Udagawa Tsuyoshi, Sato Fumiya, Tsuchiya Hikaru, Becker Thomas, Tanaka Keiji, Ingolia Nicholas T, Beckmann Roland, Inada Toshifumi

Abstract excerpt

Translation arrest by polybasic sequences induces ribosome stalling, and the arrest product is degraded by the ribosome-mediated quality control (RQC) system. Here we report that ubiquitination of the 40S ribosomal protein uS10 by the E3 ubiquitin ligase Hel2 (or RQT1) is required for RQC. We identify a RQC-trigger (RQT) subcomplex composed of the RNA helicase-family protein Slh1/Rqt2, the ubiquitin-binding...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28757607
DOI: 10.1038/s41467-017-00188-1
PMCID: PMC5534433

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