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Article

Altered Dentate Gyrus Microstructure in Individuals at High Familial Risk for Depression Predicts Future Symptoms.

Biological psychiatry. Cognitive neuroscience and neuroimaging - 1 Jan 2021

van Dijk Milenna T, Cha Jiook, Semanek David, Aw Natalie, Gameroff Marc J, Abraham Eyal, Wickramaratne Priya J, Weissman Myrna M, Posner Jonathan, Talati Ardesheer

Abstract excerpt

BACKGROUND: Offspring of individuals with major depressive disorder (MDD) are at increased risk for developing MDD themselves. Altered hippocampal, and specifically dentate gyrus (DG), structure and function may be involved in depression development. However, hippocampal abnormalities could also be a consequence of the disease. For the first time, we tested whether abnormal DG micro- and macrostructure were...

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Identifiers

PMID: 32855106
DOI: 10.1016/j.bpsc.2020.06.006
PMCID: PMC7750261

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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